Abstract: The Wangyu River is an important flood drainage channel in the Taihu Lake Basin, the Changshu Hub Project on the Wangyu River only takes the water level of Taihu Lake as the scheduling index, which cannot well balance the drainage needs of the area on the west bank of the Wangyu River (region). Through an analysis of observed water level characteristics at Taihu Lake and the regional representative station (Chenshu Station), this study identifies feasible "window periods" for the Changshu Hub to discharge regional floodwaters while maintaining Taihu Lake's outflow requirements. Furthermore, a hydrological and hydrodynamic model of river network in Taihu Lake Basin was developed to investigate optimized operation strategies for the Changshu Hub Project on the Wangyu River. The results demonstrate that, compared to the current operation scheme, incorporating Chenshu Station as a representative station increases the Changshu Hub's flood discharge volume 57 million~73 million m during peak periods under 2021 hydrological conditions. Correspondingly, the maximum water level at Chenshu Station is reduced by 41~45 cm. The relevant results can provide reference for the engineering dispatching optimization of Changshu Hub.