Abstract: Nanfei River is an important river in the main urban area of Hefei City of Anhui Province which is one of the rivers with high pressure of flood protection. In order to improve the standard for flood control of the central urban area of Hefei with a recurrence interval of 200 years in the long term, based on the current flood control systems with blocking in the upper, strengthening in the middle, discharging in the lower, and diversion in the edge, this paper analyzed and studied the optimal operation scheme of Caitang and Zhangqiao Reservoirs to control the tributary inflow by flood peakshifting regulation. The results showed that it’s an effective scheme to reduce the flood peak and the water level in the mainstream, and this paper also provided a design idea for improving the flood control standard of Hefei City.